How to Prepare for a Blood Test Measuring Inflammation Markers

Getting a blood test that measures inflammation markers is one of the simplest ways to check what’s happening inside your body. These tests can help your doctor see if your immune system is overactive or if there’s hidden inflammation that could lead to heart disease, diabetes, or other chronic conditions. But before you head to the lab, it’s important to know how to prepare properly. The results can change depending on what you eat, drink, or do before your test. Here’s what you should know to make sure your blood test results are accurate and useful.

1. Know Which Inflammation Markers Are Being Tested

Doctors often order tests like C-reactive protein (CRP), high-sensitivity CRP (hs-CRP), erythrocyte sedimentation rate (ESR), or fibrinogen. Each test measures something slightly different:

• CRP and hs-CRP detect general or low-grade inflammation, which can indicate infections or risk of heart disease.

• ESR shows how quickly red blood cells settle, another sign of inflammation.

• Fibrinogen is a blood-clotting protein that rises during inflammation.

Knowing which markers are being tested helps you follow the right preparation steps and understand your results better.

2. Follow Fasting Instructions if Needed

Some inflammation marker tests don’t require fasting. However, your doctor might combine them with other tests—like cholesterol or blood sugar levels—that do. In that case, you’ll usually be asked not to eat or drink (except water) for 8 to 12 hours before your blood draw. Always confirm with your healthcare provider if fasting is necessary.

If you do need to fast, drink only water and avoid coffee, tea, juice, or gum. Even small amounts of sugar or caffeine can affect certain results.

3. Avoid Intense Exercise Before Your Test

Heavy workouts can temporarily increase inflammation in the body, leading to higher readings. To avoid false results, it’s best to skip vigorous exercise for at least 24 hours before your blood test. Light activities like walking or stretching are fine.

4. Limit Alcohol and Processed Foods

Alcohol, fried foods, and foods high in sugar or refined carbs can trigger short-term inflammation. Try to eat clean and balanced meals in the days leading up to your test. Focus on fruits, vegetables, lean proteins, and whole grains. Staying hydrated also helps make your blood draw smoother.

5. Manage Stress and Sleep Well

Stress and lack of sleep can also raise inflammation levels. Try to get 7–8 hours of sleep the night before your test, and practice calming habits like deep breathing or meditation if you feel anxious.

6. Inform Your Doctor About Medications and Supplements

Some medicines and supplements—like nonsteroidal anti-inflammatory drugs (NSAIDs), steroids, or omega-3s—can affect inflammation results. Let your doctor know what you’re taking so they can interpret your results correctly or advise if you should pause them temporarily.

Final Tip

Preparing for a blood test measuring inflammation markers doesn’t have to be stressful. With the right steps—fasting if needed, avoiding intense exercise, eating healthy, and staying calm—you’ll help ensure accurate results. These results can guide your doctor in spotting early signs of inflammation and creating a plan to protect your long-term health.